YM说多肽|2025年全球100个重要的多肽研究课题|南京肽业
1. PepINVENT: generative peptide design beyond natural amino acids PepINVENT：超越天然氨基酸的生成式多肽设计
2. Tailored structured peptide design with a key-cutting machine approach 采用关键切割机制实现定制化结构化多肽设计
3. Artificial intelligence using a latent diffusion model enables the generation of diverse and potent antimicrobial peptides 基于隐扩散模型的人工智能实现多样化强效抗菌肽生成
4. PepMLM: A masked language model for peptide drug design PepMLM：用于多肽药物设计的掩码语言模型
5. Learning the rules of peptide self-assembly through data mining with large language models 通过大语言模型数据挖掘学习多肽自组装规律
6. De novo design of peptide inhibitors targeting GSDMD-NT pore for pyroptosis suppression 靶向 GSDMD-NT 孔道的多肽抑制剂从头设计以抑制细胞焦亡
7. Design of high-specificity binders for peptide–MHC-I complexes 多肽–MHC-I 复合物高特异性结合蛋白的设计
8. AI-driven discovery of cyclic peptides targeting KRASG12D AI 驱动发现靶向 KRASG12D 的环肽
9. Generative design of cell-penetrating peptides with enhanced endosomal escape 具有增强内体逃逸能力的细胞穿透肽生成式设计
10. Peptide design for targeted protein degradation using large language models 基于大语言模型的靶向蛋白降解多肽设计
11. Deep learning-based prediction of peptide-MHC binding affinity for cancer immunotherapy 基于深度学习的肿瘤免疫治疗多肽 - MHC 结合亲和力预测
12. De novo design of antimicrobial peptides with broad-spectrum activity against multidrug-resistant bacteria 抗多重耐药菌广谱抗菌肽的从头设计
13. AI-guided optimization of peptide-drug conjugates for targeted cancer therapy AI 指导优化用于肿瘤靶向治疗的多肽 - 药物偶联物
14. Peptide design for membrane fusion inhibition using graph neural networks 基于图神经网络的膜融合抑制多肽设计
15. Generative design of peptide-based biosensors for real-time metabolite detection 用于代谢物实时检测的多肽基生物传感器生成式设计
16. Large language models enable the design of peptides targeting intrinsically disordered proteins 大语言模型实现靶向天然无序蛋白的多肽设计
17. AI-driven discovery of peptide inhibitors for SARS-CoV-2 spike protein AI 驱动发现靶向 SARS-CoV-2 刺突蛋白的多肽抑制剂
18. Peptide design for mitochondrial targeting using deep learning 基于深度学习的线粒体靶向多肽设计
19. De novo design of peptide-based catalysts for organic synthesis 用于有机合成的多肽基催化剂从头设计
20. AI-based design of peptide vaccines for cancer immunotherapy 基于 AI 的肿瘤免疫治疗多肽疫苗设计
21. Cell-autonomous innate immunity by proteasome-derived defence peptides 蛋白酶体来源防御肽介导的细胞自主先天免疫
22. Unveiling the biosynthetic logic of nosiheptide based on reconstitution of its bicyclic thiopeptide scaffold 基于双环硫肽骨架重构揭示诺西肽的生物合成逻辑
23. A cyclic peptide antibiotic targeting bacterial cell wall synthesis with low resistance potential 一种靶向细菌细胞壁合成且低耐药性的环肽抗生素
24. Peptide-based antivirals targeting influenza A virus hemagglutinin 靶向甲型流感病毒血凝素的多肽类抗病毒药物
25. Discovery of novel antimicrobial peptides from human microbiome 从人类微生物组中发现新型抗菌肽
26. Peptide-mediated inhibition of bacterial quorum sensing for biofilm disruption 多肽介导的细菌群体感应抑制用于生物膜清除
27. A defensin-like peptide from amphibians with potent activity against Candida auris 一种来自两栖动物的防御素样多肽具有强抗耳念珠菌活性
28. Peptide-based nanomaterials for antibacterial photodynamic therapy 用于抗菌光动力治疗的多肽基纳米材料
29. Biosynthesis of lasso peptides with novel post-translational modifications 具有新型翻译后修饰的套索肽生物合成
30. Peptide inhibitors of viral entry for COVID-19 treatment 用于 COVID-19 治疗的病毒入侵抑制多肽
31. Discovery of antimicrobial peptides from marine organisms with anti-MRSA activity 从海洋生物中发现具有抗 MRSA 活性的抗菌肽
32. Peptide-mediated disruption of bacterial membrane for rapid killing of persister cells 多肽介导的细菌膜破坏用于快速杀灭持留菌
33. A novel peptide antibiotic targeting bacterial DNA gyrase 一种靶向细菌 DNA 旋转酶的新型多肽抗生素
34. Peptide-based vaccines for bacterial infections 用于细菌感染的多肽疫苗
35. Biosynthesis of thiopeptide antibiotics with enhanced antibacterial activity 具有增强抗菌活性的硫肽抗生素生物合成
36. How short peptides disassemble tau fibrils in Alzheimer’s disease 短肽如何拆解阿尔茨海默病中的 tau 蛋白纤维
37. Identification, structure, and agonist design of an androgen membrane receptor 雄激素膜受体的鉴定、结构解析与激动剂设计
38. Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis 神经酰胺通过 FPR2 受体的代谢信号抑制脂肪细胞产热
39. Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis CYSLTR2 和 P2RY6 感知神经酰胺加重动脉粥样硬化
40. A cyclic peptide inhibitor of KRASG12D with in vivo antitumor activity 一种具有体内抗肿瘤活性的 KRASG12D 环肽抑制剂
41. Peptide-drug conjugates for targeted delivery to brain tumors 用于脑肿瘤靶向递送的多肽 - 药物偶联物
42. PD-L1-targeting peptide-based immunotherapy for triple-negative breast cancer 靶向 PD-L1 的多肽基免疫治疗用于三阴性乳腺癌
43. Peptide-mediated targeted degradation of oncoproteins for cancer therapy 多肽介导的癌蛋白靶向降解用于癌症治疗
44. A peptide vaccine targeting neoantigens for personalized cancer immunotherapy 靶向新抗原的多肽疫苗用于个性化肿瘤免疫治疗
45. Peptide-based nanomedicines for synergistic cancer therapy 用于协同肿瘤治疗的多肽基纳米药物
46. HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy HIF 调控多种翻译内源性逆转录病毒：对肿瘤免疫治疗的启示
47. Peptide inhibitors of histone deacetylases for cancer treatment 用于癌症治疗的组蛋白去乙酰化酶多肽抑制剂
48. A peptide targeting tumor vasculature for anti-angiogenic cancer therapy 一种靶向肿瘤血管的多肽用于抗血管生成肿瘤治疗
49. Peptide-mediated delivery of CRISPR-Cas9 for cancer gene therapy 多肽介导的 CRISPR-Cas9 递送用于癌症基因治疗
50. A novel peptide targeting cancer stem cells for tumor eradication 一种靶向肿瘤干细胞的新型多肽用于肿瘤根除
51. Immobilized acyl-transfer molecular reactors enable the solid-phase synthesis of sterically hindered peptides 固定化酰基转移分子反应器实现位阻多肽的固相合成
52. Peptide-based rigid nanorods reinforced hydrogels for osteochondral regeneration 多肽基刚性纳米棒增强水凝胶用于骨软骨再生
53. Skin-penetrating peptides derived from computational simulation improve transdermal absorption and facilitate topical treatment of melanoma 计算模拟衍生的透皮多肽提升透皮吸收并助力黑色素瘤局部治疗
54. Programmable protein stabilization with language model-derived peptide guides 利用语言模型衍生多肽向导实现可编程蛋白质稳定
55. Peptide-drug conjugates: Trends in research and development with artificial intelligence aided design 多肽 - 药物偶联物：人工智能辅助设计的研发趋势
56. A universal peptide carrier for intracellular delivery of biologics 一种用于生物大分子胞内递送的通用多肽载体
57. Peptide-based liposomes for targeted delivery of immunotherapeutics 用于免疫治疗药物靶向递送的多肽基脂质体
58. Peptide-mediated oral delivery of insulin for diabetes treatment 多肽介导的胰岛素口服递送用于糖尿病治疗
59. Peptide-based nanoparticles for targeted delivery of siRNA to cancer cells 用于 siRNA 肿瘤细胞靶向递送的多肽基纳米颗粒
60. Peptide hydrogels for sustained release of therapeutic proteins 用于治疗性蛋白缓释的多肽水凝胶
61. Cell-penetrating peptides with enhanced stability for intracellular delivery 具有增强稳定性的细胞穿透肽用于胞内递送
62. Peptide-mediated targeted delivery of chemotherapeutics to reduce systemic toxicity 多肽介导的化疗药物靶向递送以降低全身毒性
63. Peptide-based micelles for solubilization and delivery of hydrophobic drugs 用于疏水药物增溶与递送的多肽基胶束
64. Peptide-mediated delivery of antigens for mucosal vaccination 多肽介导的抗原递送用于黏膜疫苗接种
65. Peptide-dendrimer conjugates for targeted delivery of nucleic acids 用于核酸靶向递送的多肽 - 树状大分子偶联物
66. Solid-phase synthesis of cyclic peptides via intramolecular native chemical ligation 通过分子内自然化学连接实现环肽固相合成
67. Peptide self-assembly into hierarchical nanostructures for biomaterials applications 多肽自组装形成分级纳米结构用于生物材料应用
68. De novo design of peptide nanotubes with controlled diameter and length 直径与长度可控的多肽纳米管从头设计
69. Peptide self-assembly into hydrogels for tissue engineering 多肽自组装形成水凝胶用于组织工程
70. Synthesis of mirror-image peptides for stable protein therapeutics 用于稳定蛋白治疗剂的镜像多肽合成
71. Peptide self-assembly into 2D nanosheets for electronic applications 多肽自组装形成二维纳米片用于电子应用
72. Total synthesis of large cyclic peptides via chemical ligation strategies 通过化学连接策略实现大环肽全合成
73. Peptide self-assembly into stimuli-responsive nanomaterials 多肽自组装形成刺激响应型纳米材料
74. Synthesis of peptide-drug conjugates via click chemistry 通过点击化学合成多肽 - 药物偶联物
75. Peptide self-assembly into nanofibers for wound healing 多肽自组装形成纳米纤维用于伤口愈合
76. Single-Position Peptide Clustering for Peptidomics Reveals Novel Disease Biomarkers and Dysregulated Proteolytic Characteristics 多肽组学的单位置多肽聚类揭示新型疾病生物标志物与失调的蛋白水解特征
77. Peptidomics reveals novel biomarkers for early diagnosis of pancreatic cancer 多肽组学揭示胰腺癌早期诊断的新型生物标志物
78. Mass spectrometry-based peptidomics for biomarker discovery in neurodegenerative diseases 基于质谱的多肽组学用于神经退行性疾病生物标志物发现
79. Peptidomics analysis of cerebrospinal fluid for Alzheimer’s disease diagnosis 用于阿尔茨海默病诊断的脑脊液多肽组学分析
80. Peptidomics identifies novel peptide biomarkers for cardiovascular diseases 多肽组学鉴定心血管疾病的新型多肽生物标志物
81. Peptidomics of tumor microenvironment reveals novel immunomodulatory peptides 肿瘤微环境多肽组学揭示新型免疫调节多肽
82. Peptidomics analysis of urine for early detection of kidney disease 用于肾病早期检测的尿液多肽组学分析
83. Peptidomics reveals novel peptide regulators of immune cell function 多肽组学揭示免疫细胞功能的新型多肽调控因子
84. Peptidomics of extracellular vesicles for biomarker discovery 细胞外囊泡多肽组学用于生物标志物发现
85. Peptidomics analysis of plasma for metabolic disease biomarkers 用于代谢疾病生物标志物的血浆多肽组学分析
86. A novel peptide hormone regulating glucose homeostasis 一种调控葡萄糖稳态的新型多肽激素
87. Peptide-mediated regulation of circadian rhythm 多肽介导的昼夜节律调控
88. Neuropeptides regulating appetite and energy balance 调控食欲与能量平衡的神经肽
89. Peptide-based therapeutics for neurodegenerative diseases 用于神经退行性疾病的多肽基治疗药物
90. A novel neuropeptide regulating pain perception 一种调控疼痛感知的新型神经肽
91. De novo design of voltage-gated anion channels from peptides 基于多肽的电压门控阴离子通道从头设计
92. Peptide-based artificial enzymes for catalytic reactions 用于催化反应的多肽基人工酶
93. Peptide-mediated regulation of stem cell fate 多肽介导的干细胞命运调控
94. Peptide-based biosensors for real-time detection of biomolecules 用于生物分子实时检测的多肽基生物传感器
95. Peptide-mediated control of gene expression 多肽介导的基因表达调控
96. Peptide-based materials for energy storage applications 用于储能应用的多肽基材料
97. Peptide-mediated regulation of autophagy 多肽介导的自噬调控
98. Peptide-based vaccines for infectious diseases 用于感染性疾病的多肽疫苗
99. Peptide-mediated targeting of intracellular organelles 多肽介导的细胞内细胞器靶向
100. Peptide-based strategies for protein misfolding diseases 用于蛋白质错误折叠疾病的多肽基策略
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